![]() Participate in water activities on Lake Erie ( on Ohio's northern border. Along with old, picturesque homes, it offers impressive historical sights such as Inscription Rock, an exceptionally large Native American pictograph. Kelleys IslandĮxplore Kelleys Island ( on the National Register of Historic Places. Attend a musical drama in the outdoor amphitheatre (seating 1,600) at the Johnny Appleseed Heritage Center ( in Ashland. Visit Johnny Appleseed country in the picturesque north central region. Tour Cleveland's Holden Arboretum ( one of the largest arboreta and botanical gardens in the USA. Go underground in Hocking Hills State Park to explore Ash Cave, Ohio's largest recess cave, which features a 27m- (90ft-) high waterfall ( While you’re there, don't miss the Rock House (a series of large rooms mysteriously carved into the side of a cliff), the 46m- (150ft-) high Cantwell Cliffs and Hocking Forest, where rock climbing is permitted. German VillageĮnjoy a touch of German culture in Columbus at the lavishly restored German Village ( ), complete with fine restaurants and taverns, and the 11-hectare (27-acre) Brewery District, which you’ll find packed with with vintage beer-making factories now converted into restaurants, speciality shops and taverns. Kids and parents alike will also enjoy the Hale Farm and Village ( a living-history museum depicting life in the mid 19th century. Cuyahoga Valley National Recreation Areaįind many nature-based activities in the 13,355-hectare (33,000-acre) Cuyahoga Valley National Recreation Area ( The 35km- (22-mile-) long river surrounded by steep, forested hills, sandstone gorges and hidden waterfalls is popular with birdwatchers and hikers. ![]() See five history galleries, changing exhibits, and a Slave Jail. ![]() Tour Cincinnati's National Underground Railroad Freedom Center ( focusing on the struggle for freedom experienced by runaway slaves. Grab a hotdog and watch a ballgame with either of the state's two pro baseball teams: the Cincinnati Reds ( and the Cleveland Indians ( Cincinnati's National Underground Railroad Freedom Center Cincinnati Reds and Cleveland Indians Baseball Spend the day riding rollercoasters at Cedar Point Amusement Park ( or Kings Island Theme Park and Soak City ( featuring over 50 wet-and-wild activities. Things to see and do in Ohio Attractions in Ohio African Safari Wildlife ParkĮxperience the Midwest's only drive-through safari at Ohio's African Safari Wildlife Park ( Animal lovers can also head to the Cleveland Metroparks Zoo ( which allows visitors to wander through such colourful habitats as The Rainforest, the Australian Adventure, and the Waterfowl Lake.
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![]() Whether you're producing your next song or arranging audio for live performances, Ableton Live 11 Suite will give you everything you need to create musical history. This version includes over 70 GB of sounds, 17 software instruments and 59 audio effects. A variety of new sounds are also introduced with Live 11 including new sample packs and virtual instruments designed in collaboration with Spitfire Audio (exclusive to Suite). One such new feature is 'Tempo Following' allowing Live to listen to incoming audio and adjust the project tempo in real-time. Not only is it great for the studio, but it also has a range of performance features you can use on stage. Record, arrange, edit, mix and master your music with ease using the powerful tools on offer within Ableton Live 11. Thanks to cutting-edge new tools you can now comp and record, allowing you to piece together multiple recordings to create the perfect take. With a whole host of new features, sounds and instruments, Ableton Live 11 allows you to capture inspiration when it strikes. For full information on our returns policy, please refer to our returns and refunds information guide.Ībleton Live 11 Suite is the most comprehensive version of the award-winning digital audio workstation. ![]() We are unable to accept returns of any custom made items designed to work together as a unique package and some items are only eligible for money back guarantee if they are returned to us unused and sealed in the original packaging. This table provides an overview of your statutory consumer rights, compared with our standard returns policy and optional extended money back guarantee and warranty.įree collection if defective, delivered damaged or incorrect item Summary of returns policies and timescales When returning an order please ensure products are appropriately packaged and protected, to prevent them from getting damaged. In the unlikely event that any item in this order is faulty, damaged or incorrect on receipt, notify us within 14 days and we'll arrange a free collection. The collection fee can be found in the returns information on each product's page on Gear4music. ![]() We can collect your return for a small fee, or you can send it back to us yourself. Reeds and mouthpieces for woodwind and brass instruments Important: For hygiene and software licensing reasons, some items are only eligible for our Money Back Guarantee if they are returned to us unused and sealed in the original packaging with all software still "unregistered." Details of exclusions are shown within the product descriptions. Please keep hold of all the original packaging until you're sure you want to keep the order. If you decide your order isn't suitable for any reason you can return it - just let us know within 30 days of receiving it. ![]() At the wall edges, install a finishing border made of wood or any other material that blends with the décor and ceiling.Now install the joint strips if your tiles come with any.Install the border (non-full size) tiles.Apply the adhesive and install the main (full-size) tiles.Cut the tiles properly to fit the layout.Plan how you’ll lay out the ceiling tiles.Here’s how to install glue-up vinyl ceiling tiles: Installing vinyl ceiling tiles is extremely easy, and many people can do it themselves. Also, since the protective sheen maintains its glossy new look, you won’t have to worry about cleaning methods that keep it looking new. Dust doesn’t embed into the tiles most common detergents won’t corrode them, so when cleaning, just wipe, and that’s it. If you’re one of the many people who hate high maintenance ceilings, a vinyl one will serve you well. If it looks great, you’ll probably attract a higher price. You can add a vinyl ceiling to your current home to raise its value. ![]() If installed well, they won’t look cheap at all. You can get plain, antique, exotic, and other designs. They come in a range of colors, shapes, and patterns that mimic all sorts of desirable graphics. If you like having design options during your purchase, vinyl ceiling tiles might be your best bet. So even if you live in an area with high humidity, a vinyl ceiling can serve you for ten years or more. Since vinyl ceiling tiles contain a protective sheen commonly made of polyurethane, they can’t absorb moisture from the air. But just like vinyl flooring, vinyl ceiling tiles are more resilient. Some materials absorb moisture in the air so fast that the ceiling loses value rapidly. One of the worst issues you may generally have with ceiling tiles is humidity. Therefore, vinyl ceiling tiles are an excellent option for a great look at a low price. Even if you’re getting high-grade vinyl ceiling tiles, you’ll find them to be less expensive than other alternatives. Vinyl ceiling tiles are produced in massive numbers, so the cost of production ends up being low. They are cheaper than fiberglass and wood fiber ceiling tiles, among others. AffordableĬompared to other ceiling materials, vinyl ceiling tiles are budget-friendly. So, they’re not only durable, but they are also not bulky. They can last long no matter their thickness since vinyl is very flexible because of plasticizers. ![]() Never be worried if the vinyl tiles you receive are thin. Their robust build and protective coating make them resistant to one of the most destructive elements: moisture. So how long do vinyl ceiling tiles last? They can last a decade or even more. Vinyl is built to be highly durable that’s why it’s showing up in many products each day. The following are the pros of vinyl ceiling tiles: 1. They easily match with modern and contemporary décor, and they are now readily available at a price most people can afford. The benefits of vinyl ceiling tiles are enough to entice you to get some installed. This article will delve deeper into the advantages and disadvantages of vinyl ceiling tiles, after which you can explore the best options available and their alternatives. ![]() Some of the pros and cons of vinyl ceiling tiles to help you decide their worth are:Īll ceiling tiles have good and bad qualities, but knowing them all in detail is what helps you choose the most suitable for your project. They work well and match with modern and contemporary decor in both residential and commercial settings. Vinyl ceiling tiles, also known as PVC ceilings, are currently trending. We may also earn commissions if you purchase products from other retailers after clicking on a link from our site. As an Amazon Associate, we earn from qualifying purchases. Affiliate Disclaimer: This page may contain affiliate links. In fact, seven human antibodies approved for clinical use by the US Food and Drug Administration were discovered using transgenic mice first developed over 20 years ago 5. This approach allows highly evolved in vivo mechanisms, such as hypermutation in germinal centers, to be exploited to generate high-affinity antibodies with optimal biophysical properties 2, 3, 4. One attractive approach for generating fully human antibodies is to use transgenic animals engineered to express a human antibody repertoire. They can also be immunogenic in patients, leading to attenuation of their efficacy over time. These antibodies often have suboptimal biophysical attributes, leading to difficulties in manufacture and in poor pharmacokinetics. However, antibodies discovered using phage libraries show limited diversity and non-native pairing of immunoglobulin heavy and light chains moreover, improving their affinity requires iterative, time-consuming, in vitro methods, which take place outside the natural controls on a mammalian B cell. More recently, fully human antibodies have been generated using phage libraries and transgenic animals. The first approved therapeutic monoclonal antibodies (mAbs) were derived by humanization of rodent antibodies. In drug development, antibodies are often preferred over small molecules since they are natural products with exquisite specificity and potency, have a known volume of distribution in the body and generally have superior safety profiles. These mice provide a robust system for the discovery of therapeutic human monoclonal antibodies as a surrogate readout of the human antibody response, they may also aid vaccine design efforts.Īntibodies constitute the fastest-growing and most advanced class of pharmaceuticals today 1. Antigen immunization results in production of high-affinity antibodies with long human-like complementarity-determining region 3 (CDR3H), broad epitope coverage and strong signatures of somatic hypermutation. These transgenic mice are viable and fertile, with an immune system resembling that of wild-type mice. Here, using repetitive cycles of genome engineering in embryonic stem cells, we have inserted the entire human immunoglobulin variable-gene repertoire (2.7 Mb) into the mouse genome, leaving the mouse constant regions intact. However, technical limitations inherent to conventional transgenic technology and sequence divergence between the human and mouse immunoglobulin constant regions limit the utility of these mice. If immunized with an antigen of interest, transgenic mice with large portions of unrearranged human immunoglobulin loci can produce fully human antigen-specific antibodies several such antibodies are in clinical use.
The annotation layers are numbered beginning with "0" at the bottom of the layer list. "Annotations" as well as "True" and "False" have to be written with a capital first letter (but not the entire word!) so that Blender and Python can recognize it: This will definitely be an option in the next version of Sensei must use single or double quotation marks: "Annotations" or 'Annotations'. You would have to run the code though for every new annotation layer you create, so maybe make a few dedicated layers and name them "non see-through" or something for when you want to use annotations that aren't see through.Įven if this option never returns to the default UI, would be pretty easy to create an addon that handles this. A fix for right now would be to paste in and run the code (after opening a new blank file) then go to File > Defaults > Save Startup File. If it is somewhere (as of Blender 2.82), please someone let me know where. I'm not sure why this was not kept accessible in the default UI for annotations. for layer in _pencils.layers: layer.show_in_front=False Or this to change all existing annotation layers. Copy this line, go to the Scripting workspace, paste this in the console (place where you see >) and press Enter. ![]() ![]() To my knowledge there's nowhere currently in the front end UI to do this for annotations though. This can be done with annotations programmatically. In the section of thank-yous, the speech turned fractionally more serious, and Louis-Dreyfus wound her way toward her health. “ ‘Then I reread the e-mail and I realized-it’s me! They’re giving it to me! And I get the prize! And my attitude about the whole thing changed, it really did.’ ” I have to go all the way to Washington, D.C.-which, no offense, is a nightmare-and get a dress and all that crap, and make up flowery things to say about how funny someone else is? No effing way.’ ” The writers tittered. “ ‘When Mark Twain first e-mailed me about the prize, I totally misunderstood: I assumed that I was being asked to honor somebody else, and I thought, Oh, my God, what a hassle. “O.K., should we hear this thing and see how bad it is?” she asked, and began to read. Asked how it was, she replied, “Punitive.”) She leafed through a printout of the speech. (Mountains of dumplings from Din Tai Fung for the writers, and a spinach salad for Louis-Dreyfus, which her assistant handed her in a Tupperware. ![]() Later that day, she sat with the showrunner of “Veep,” David Mandel, in a small conference room in the Hilton, surrounded by a dozen writers and assistants, who were helping Louis-Dreyfus fine-tune her speech over lunch. She’d decided to address her illness and recovery at the Twain prize, but, as she put it, “I don’t want it to be ‘The Cancer Show at the Kennedy Center.’ ” ![]() These days, it is also “blasted by chemotherapy and still growing out,” after six rounds of treatment that Louis-Dreyfus underwent last year for breast cancer. Her real hair is explosively curly, when it hasn’t been coaxed into sleekness for an event. When the makeup was finished, a stylist ran a curling iron through Louis-Dreyfus’s shiny brown bob, one of several wigs she’s worn while making “Veep,” in order to minimize her preparation time. She was sitting in a white bathrobe, having her makeup done, in a room at the Glendale Hilton, where she was shooting an episode of her HBO series, “ Veep.” Louis-Dreyfus has nine Screen Actors Guild Awards and a Golden Globe, and she shares with Cloris Leachman the record for the most Emmys accumulated by an actor: one for playing Elaine Benes, on “Seinfeld,” the role that made her a star one for her performance in “ The New Adventures of Old Christine” and six for playing Selina Meyer, on “Veep.” But the Twain prize felt different. “It’s, like, ‘If you’re so fucking funny, get up onstage and prove it!’ ” she said one morning in Los Angeles. ![]() In a few weeks, she would be receiving the Mark Twain Prize for American Humor, in a televised ceremony at the Kennedy Center, and she was anxious about her speech. Julia Louis-Dreyfus was not feeling relaxed. ![]() The silky smooth cranberry curd is such a fun change of pace from how cranberries are traditionally enjoyed.Īnd, not only is the appearance downright jaw-dropping on the table, it’s one of those recipes you’ll feel so proud of and accomplished at the end. ![]() If you’re a cranberry lover, I think you will absolutely adore this tart recipe. This apricot brandy cake has been a longstanding tradition in my family.īut this year, since it’s 2020 and all bets seem to be off, why not try something new? I know we all tend to have our traditions when it comes to holiday desserts. TRY THIS CRANBERRY CURD TART FOR THE HOLIDAYS THIS YEAR Plus, the cranberry curd is texturally so smooth and silky it’s literally like a forkful of pure bliss with each bite. Not only do you get the tartness and sweet taste from the fruit, this oat and walnut tart crust is leaps and bounds easier to put together than a pastry pie crust. My sour cherry crisp recipe is the perfect lazy approach to cherry pie btw.īut, I think I may have found an even greater love with this cranberry curd tart. I’m not even picky on the fruit (although berry and cherry pies are my favorite), I just love the combination of tart and sweet with my pastry, something cream pies seldom offer. When it comes to desserts I’m a sucker for a good homemade fruit pie. This cranberry curd tart is what dreams are made of when it comes to festive desserts.Ī silky smooth, brightly tart and just perfectly sweet cranberry curd filling inside a tart crust made from oats and walnuts is not only beyond delightful in taste, it’s a true showstopper as the sweet centerpiece on your holiday table. Oh boy, do I have a stunning holiday dessert for you! This cranberry curd tart features a smooth sweet and tart cranberry curd filling inside a gluten-free oat and nut-based crust that results in a stunningly delicious and festive holiday dessert. (2002), transplantation of NSCs into a rat model of spinal cord injury resulted in improved functional recovery and increased regeneration of damaged axons. ![]() Spinal cord injury: In a study by Hofstetter et al.(2001) showed that transplantation of NSCs in a rat stroke model resulted in improved functional recovery, reduced infarct size, and increased angiogenesis. Multiple sclerosis (MS): In a preclinical study, the transplantation of MSCs in an animal model of MS resulted in reduced inflammation and demyelination, as well as improved neurological function (Zappia et al., 2005).Parkinson's disease: Studies have shown that transplantation of stems cell-derived dopaminergic neurons into animal models of Parkinson's disease can improve motor function and alleviate symptoms (Kim et al., 2002).Several peer-reviewed studies have demonstrated the therapeutic potential of stem cell therapy in specific neurological disorders: This modulation may facilitate nerve regeneration by removing physical barriers to nerve growth. Stem cells, particularly MSCs, have been shown to modulate glial scar formation by reducing the proliferation of astrocytes and promoting the production of matrix metalloproteinases (MMPs), which help break down the scar tissue (Zhang et al., 2013). Modulation of glial scar formation: Glial scar formation can inhibit nerve regeneration in the central nervous system (CNS) following injury.This ability allows stem cells to directly contribute to repairing and regenerating the damaged nervous tissue by replacing lost or damaged cells. Differentiation into neural cells: Stem cells, particularly neural stem cells (NSCs), can differentiate into various neural cell types, such as neurons, astrocytes, and oligodendrocytes (Gage, 2000).This process improves blood flow, oxygen, and nutrient delivery to the injured tissue, promoting healing. Angiogenesis: Stem cells, particularly MSCs, have been shown to promote the formation of new blood vessels by secreting pro-angiogenic factors, such as vascular endothelial growth factor (VEGF) (Kinnaird et al., 2004).Immunomodulation: Stem cells, particularly MSCs, have demonstrated immunomodulatory properties by suppressing the activation of pro-inflammatory immune cells, such as T cells and macrophages, and promoting the production of anti-inflammatory cytokines, such as interleukin-10 (IL-10) and transforming growth factor-beta (TGF-β) (Uccelli et al., 2008).Neuroprotection: Stem cells, particularly mesenchymal stem cells (MSCs), have been shown to provide neuroprotection by secreting neurotrophic factors, such as brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF), which promote neuronal survival and reduce apoptosis (Lu et al., 2005).Some of functions of transplanted cells include: Although the exact mechanisms may vary depending on the specific disease, several standard processes have been identified through peer-reviewed studies that contribute to the therapeutic effects of stem cells in neurological conditions. Stem cell therapy has emerged as a promising avenue for treating neurological disorders. How Stem Cell Therapy Works for Neurological Disorders Stem cells can self-renew and differentiate into specialized cells, making them an ideal candidate for treating multiple medical conditions, including neurological disorders. Stem cell therapy involves using stem cells, which are unspecialized cells capable of developing into various cell types (including human neural stem cells), treating diseases, or repairing damaged tissues. Overview of Stem Cell Therapy for Neurological Conditions Some common neurological disorders include: They can manifest in various ways, including cognitive decline, movement disorders, seizures, and pain. Neurological disorders are diseases affecting the brain, spinal cord, and nerves. This article explores how stem cells can treat neurological conditions, the advantages and disadvantages of this therapy, its success rates, and the best stem cell therapy centers worldwide. In recent years, stem cell therapy for neurological disorders has emerged as a promising treatment option. However, stem cell therapies promise to reduce the neurological symptoms associated with these diseases. One area that can be negatively affected by aging is the development of brain disorders and the body's natural stem cells, known as endogenous stem cells. ![]() Aging is a multifaceted process that impacts various aspects of the human body. ![]() Neurological disorders can be debilitating and life-altering. FeaturesĬubase Pro offers everything Cubase Artist offers and more. About Cubase ProĬubase Pro is a full-featured DAW with one of the most extensive MIDI tracking libraries. The memory management is superior to most DAWs, and the audio interface is first in class.Ĭubase works great for musical notation and video integration. Though the Pro version has a steep learning curve, it’s easy to use once you get used to it. It’s versatile for all music genres and is used for recording, mastering, film scoring, editing, and mixing. Cubase ProĬubase Pro offers studio-quality audio at every stage of the creative process. To run Cubase Artist, you need the Steinberg USB eLicenser, which comes with your package. Cubase takes up space and will need at least 35GB of free space on your hard disk. Your processor needs to be at least Intel i5 or faster, with a minimum of 4GB RAM. For Windows PC’s you will need the 64-bit Windows 10 version 2004 or higher. If you are using an Apple computer, you need to be running a macOS Catalina, macOS Mojave, or macOS Big Sur. Cubase Artist System RequirementsĪccording to, Cubase has a higher system requirement than most other DAWs. It’s the perfect tool for mid-level mixing, recording, and editing of audio productions.Ĭubase Artist is designed to meet the needs of seasoned musicians, bands, and project studio operators. What Is It Good ForĬubase Artist allows music production right from your computer. The USB eLicenser retails at EUR 22.99 per unit but if you already have one then get Cubase Artist at EUR 309.99. These include Halion Sonic SE, Virtual Analogue Synthesizer, Groove Agent SE 5, Padshop 2, and Retrologue 2.Ĭubase Artist 11 Full version goes for EUR 331.99. 8 premium instruments playing over 2,600 different sounds.VariAudio3 for precision tuning monophonic of instruments such as vocals.Pitch Correct for vocal editing, including VST Amp Rack and VST Bass Amp.Up to 32 physical inputs and outputs to support unlimited audio, instrument, and midi tracks.This is a fantastic tool for artists who want to produce acapella or music remixes. ![]() The artist includes Spectralayers One, which allows the extraction of instrumentals and vocals out of any stereo audio file.Some of the key features of Cubase Artist include: As you get familiar with the software, you can upgrade to Cubase Pro. If you run a home studio or a small commercial studio, you can start with Cubase Artist. About Cubase ArtistĬubase works best for recording, editing, and producing music. You can even copy ideas copies and takes and paste them at any point in your new project. With Cubase Artist, you can mix up to 128 midi and 64 audio tracks on the large screen console. These are the building blocks from which you can draw inspiration and create music sketches, soundtracks, and full song productions. Cubase Artist comes with thousands of midi construction kits, loops, and samples. ![]() Recording, editing, and producing music in Cubase Artist can provide an unmatched delight.
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